Levetiracetam in primary orthostatic tremor: A double‐blind placebo‐controlled crossover study
Identifieur interne : 000271 ( Main/Exploration ); précédent : 000270; suivant : 000272Levetiracetam in primary orthostatic tremor: A double‐blind placebo‐controlled crossover study
Auteurs : Helge Hellriegel [Allemagne] ; Jan Raethjen [Allemagne] ; G. Deuschl [Allemagne] ; Jens Volkmann [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-11.
English descriptors
Abstract
Background:: In a double‐blind crossover study we evaluated the antitremor effect of a 4‐week treatment with either escalating dosages of levetiracetam or placebo in orthostatic tremor. Methods:: Twelve patients with orthostatic tremor participated in the study. Primary end point was improvement in stance duration. Secondary end points were total track length of the sway path and tremor total power. The patients' impression of impairment was assessed by a visual analog scale and quality of life by the SF‐36. Results:: We found no significant effect of dosage or treatment on stance duration (P = .175), total track length (P = .690), total power (P = .280), or visual analog scale (P =.735). Neither was SF‐36 differentially changed by levetiracetam or placebo (SF‐36, Physical Component Summary: P = .079; SF‐36, Mental Component Summary: P = .073). Side effects like dizziness, fatigue, or nausea were only mild to moderate. Conclusions:: Levetiracetam is ineffective in the treatment of orthostatic tremor. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23881
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Deuschl</name></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7D8F27B5732B3628C308C61E644D79ABC4F58DDF</idno><date when="2011" year="2011">2011</date><idno type="doi">10.1002/mds.23881</idno><idno type="url">https://api.istex.fr/document/7D8F27B5732B3628C308C61E644D79ABC4F58DDF/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">002107</idno><idno type="wicri:Area/Main/Curation">001E03</idno><idno type="wicri:Area/Main/Exploration">000271</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Levetiracetam in primary orthostatic tremor: A double‐blind placebo‐controlled crossover study</title><author><name sortKey="Hellriegel, Helge" sort="Hellriegel, Helge" uniqKey="Hellriegel H" first="Helge" last="Hellriegel">Helge Hellriegel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts‐University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Raethjen, Jan" sort="Raethjen, Jan" uniqKey="Raethjen J" first="Jan" last="Raethjen">Jan Raethjen</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts‐University, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Deuschl, G" sort="Deuschl, G" uniqKey="Deuschl G" first="G." last="Deuschl">G. 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-11">2011-11</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">13</biblScope><biblScope unit="page" from="2431">2431</biblScope><biblScope unit="page" to="2434">2434</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">7D8F27B5732B3628C308C61E644D79ABC4F58DDF</idno><idno type="DOI">10.1002/mds.23881</idno><idno type="ArticleID">MDS23881</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>clinical neurology</term><term>clinical trials</term><term>levetiracetam</term><term>orthostatic tremor</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: In a double‐blind crossover study we evaluated the antitremor effect of a 4‐week treatment with either escalating dosages of levetiracetam or placebo in orthostatic tremor. Methods:: Twelve patients with orthostatic tremor participated in the study. Primary end point was improvement in stance duration. Secondary end points were total track length of the sway path and tremor total power. The patients' impression of impairment was assessed by a visual analog scale and quality of life by the SF‐36. Results:: We found no significant effect of dosage or treatment on stance duration (P = .175), total track length (P = .690), total power (P = .280), or visual analog scale (P =.735). Neither was SF‐36 differentially changed by levetiracetam or placebo (SF‐36, Physical Component Summary: P = .079; SF‐36, Mental Component Summary: P = .073). Side effects like dizziness, fatigue, or nausea were only mild to moderate. Conclusions:: Levetiracetam is ineffective in the treatment of orthostatic tremor. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Schleswig-Holstein</li></region><settlement><li>Kiel</li></settlement></list><tree><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Hellriegel, Helge" sort="Hellriegel, Helge" uniqKey="Hellriegel H" first="Helge" last="Hellriegel">Helge Hellriegel</name></region><name sortKey="Deuschl, G" sort="Deuschl, G" uniqKey="Deuschl G" first="G." last="Deuschl">G. Deuschl</name><name sortKey="Raethjen, Jan" sort="Raethjen, Jan" uniqKey="Raethjen J" first="Jan" last="Raethjen">Jan Raethjen</name><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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